Primary Antibodies 

Primary antibodies from AffiNEURO are designed for high specificity and sensitivity in detecting neurobiological targets. These antibodies are integral to research and diagnostic workflows, directly binding to antigens of interest. Available in both monoclonal and polyclonal formats, they are optimized for applications across neuroscience, clinical studies, and therapeutic research.

Content and Characteristics:

• Source Types:
  • Monoclonal Antibodies (mAbs): Derived from a single B-cell clone, ensuring high specificity to a single epitope.
  • Polyclonal Antibodies (pAbs): Sourced from immunized animals, recognizing multiple epitopes on the same antigen for enhanced signal detection.
• Antigen Targets:
  • Neural markers: Synaptic proteins, neurotransmitters, neurotrophic factors, and disease-associated proteins.
  • Common targets include GFAP, Iba1, amyloid-β, tau, dopamine receptors, and BDNF.
• Validation and Purity:
  • Extensively tested for applications like immunohistochemistry (IHC), Western blotting (WB), immunofluorescence (IF), ELISA, and flow cytometry (FC).
  • Available in affinity-purified formats for increased specificity and reduced background noise.

Applications:

• Neuroscience Research:
  • Identify and quantify proteins critical to synaptic function, neural signaling, and plasticity.
  • Study the molecular mechanisms underlying neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
• Clinical Diagnostics:
  • Measure disease biomarkers in patient samples (e.g., CSF, plasma, or serum).
  • Detect inflammation or neurodegeneration markers in diagnostic workflows.
• Therapeutic Research:
  • Validate therapeutic targets in drug development pipelines.
  • Monitor changes in biomarker expression in response to experimental treatments.
• Immunodetection Techniques:
  • Western Blotting (WB): Detect protein presence and size.
  • Immunohistochemistry (IHC): Visualize protein localization in tissue sections.
• • Flow Cytometry (FC): Quantify protein expression on or within cell populations.

AffiNEURO offers technical support and detailed datasheets for each primary antibody, including recommended dilutions, validated applications, and storage conditions. For more information, consult the AffiNEURO website or technical team.