Monoclonal Antibodies
Monoclonal antibodies (mAbs) developed by AffiNEURO are highly specific tools used for the detection, quantification, and manipulation of neurobiological targets. These antibodies are produced from a single clone of B cells, ensuring homogeneity and specificity toward a single epitope on the target antigen.
Content and Characteristics:
- Production:
- Hybridoma Technology: Monoclonal antibodies are generated using hybridoma technology, where a single B cell is fused with a myeloma cell, resulting in a hybrid cell line capable of continuous antibody production.
- Recombinant Technology: Advanced mAbs are produced using recombinant DNA methods to enhance purity, reproducibility, and customization.
- Specificity and Affinity:
- High specificity for neural targets, such as neurotransmitters, receptors, neurotrophic factors, or disease-associated proteins.
- Superior binding affinity ensures reliable and consistent results.
- Formats:
- Available as unlabeled antibodies or conjugated with fluorescent dyes, enzymes (e.g., HRP, AP), or biotin for diverse applications.
- Multiple isotypes, such as IgG1, IgG2a, and IgM, tailored for specific experimental needs.
Applications:
- Neuroscience Research:
- Biomarker Detection: Detect and quantify biomarkers associated with neurological development, synaptic function, or neurodegeneration (e.g., amyloid-β, tau proteins).
- Pathway Studies: Investigate signaling pathways and molecular interactions in neuronal cells.
- Disease Modeling:
- Neurodegenerative Disorders: Study pathophysiological mechanisms in diseases like Alzheimer’s, Parkinson’s, and Huntington’s.
- Neuroinflammatory Conditions: Analyze markers of inflammation in the central nervous system (e.g., microglial activation).
- Drug Development:
- Validate therapeutic targets and assess drug efficacy in preclinical studies.
- Monitor pharmacodynamic and pharmacokinetic profiles of therapeutic agents.
For detailed product specifications, datasheets, and ordering information, consult AffiNEURO's official resources or technical support team.
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