Polyclonal Antibody
Polyclonal antibodies (pAbs) by AffiNEURO are versatile tools used in neurobiological research and diagnostics. Unlike monoclonal antibodies, polyclonal antibodies are a heterogeneous mix of immunoglobulin molecules produced by different B-cell clones. This diversity enables them to bind multiple epitopes on the same antigen, providing enhanced signal strength and sensitivity in various applications.
Content and Characteristics:
- Production:
- Derived from the immunization of host animals (e.g., rabbits, goats, or mice) with the target antigen.
- Collected from the serum of immunized animals after an appropriate immune response has been generated.
- Binding Properties:
- Recognize and bind multiple epitopes on the target protein.
- Offer higher overall affinity due to multi-epitope recognition.
- Format and Purity:
- Provided as crude serum, affinity-purified antibodies, or IgG fractions for different research needs.
- Available with or without conjugation to enzymes (HRP, AP) or fluorescent dyes.
Applications:
- Neuroscience Research:
- Neurobiological Studies: Ideal for detecting complex protein conformations, post-translational modifications, and neuro-specific antigens.
- Synaptic Function Analysis: Study synaptic proteins and their role in neurotransmission.
- Diagnostics:
- Detect biomarkers of neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s).
- Broad epitope coverage is advantageous for capturing antigen variants in diagnostic assays.
- Signal Amplification:
- Superior detection sensitivity in assays requiring strong signals due to multi-epitope binding.
- Epitope Mapping:
- Helpful for identifying regions of antigenicity on neural proteins.
- Drug Discovery and Development:
- Validate target engagement and assess efficacy in therapeutic studies.
For detailed product information, datasheets, and technical support, consult the official AffiNEURO resources or contact their technical support team.
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